Research Publications, Abstracts, Talks
Research Publications, Peer Reviewed
1. T.D. Edlind, K.W. Henry, J.P. Vermitsky, M.P. Edlind, S. Raj, S.K. Katiyar. (2005) Promoter-dependent disruption of genes: simple, rapid, and specific PCR-based method with application to three different yeast. Curr. Genet. 48:117-125.
2. W.S. Lo, E.R. Gamache, K.W. Henry, D. Yang, L. Pillus, S.L. Berger. (2005) Activator-targeted Snf1-mediated histone H3 phosphorylation promotes TBP recruitment through distinct promoter-specific mechanisms. EMBO J. 24:997-1008.
3. N.C.T. Emre, K. Ingvarsdottir, A. Wyce, A. Wood, N.J. Krogan, K.W. Henry, K. Li, J.F. Greenblatt, R. Mormorstein, A. Shilatifard, S.L. Berger. (2005) Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere proximal Sir2 association and gene silencing. Mol. Cell. 17:585-594.
4. C.F. Kao, C. Hillyer, T. Tsukuda, K. Henry, S. Berger, M.A. Osley. (2004) Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. Genes Dev. 22:184-195.
5. K.W. Henry, A. Wyce, W.S. Lo, L.J. Duggan, N.T. Emre, C.F. Kao, M.A. Osley, S.L. Berger. (2003) Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev. 21:2648-2663.
6. K.W. Henry, J.T. Nickels, and T.D. Edlind. (2002) ROX1 and ERG regulation in Saccharomyces cerevisiae: implications for antifungal susceptibility. Euk. Cell. 1:1041-1044.
7. T.D. Edlind, L. Smith, K.W. Henry, S.K. Katiyar, J.T. Nickels. (2002) Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signaling. Mol. Microbiol. 46:257-268.
8. T.D. Edlind, K.W. Henry, K. Metera, and S.K. Katiyar. (2001) Aspergillus fumigatus CYP51 sequence: potential basis for fluconazole resistance. Med. Mycol. 39:299-302.
9. K. Baudry, E. Swain, A. Rahier, M. Germann, A. Batta, S. Rondet, S. Mandala, K.W. Henry, G.S. Tint, T.D. Edlind, M. Kurtz, and J.T. Nickels. (2001) The effect of the erg26-1 mutation on the regulation of lipid metabolism in Saccharomyces cerevisiae. J. Biol. Chem. 276:12702-12711.
10. K.W. Henry, J.T. Nickels, and T.D. Edlind. (2000) Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob. Agents Chemother. 44:2693-2700.
11. K.W. Henry, M.C. Cruz, S.K. Katiyar and T.D. Edlind. (1999) Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents. Antimicrob. Agents Chemother. 43:1968-1974.
Review Articles
1. M.W. Mather, K.W. Henry, A.B. Vaidya. (2007) Mitochondrial drug targets in apicomplexan parasites. In press, Curr. Drug Targets. 8(1):49-60.
2. W.S. Lo, K.W. Henry, M.F. Schwartz, S.L. Berger. (2004) Histone modification patterns during gene activation. Meth. Enzym. 377:130-153.
3. A. Wyce, K.W. Henry, S.L. Berger. (2004) H2B ubiquitylation and de-ubiquitylation in gene activation. Novartis Found. Symp. 259:63-73.
4. K.W. Henry, S.L. Berger. (2002) Trans-tail histone modifications: wedge or bridge? Nat. Struct. Biol. 9:565-566.
Abstracts
1. Histone modifications regulate antifungal sensitivity and MDR gene expression in Candida glabrata. K.W. Henry, J.P. Vermitsky, W.L. Smith, T.D. Edlind. ASM Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September, 2006. San Francisco, CA.
2. A candidate Candida glabrata virulence factor: catalase-mediated hydrogen peroxide resistance. T.D. Edlind, J.P. Vermitsky, J. Andrews, W.L. Smith, K.W. Henry, S.K. Katiyar, ICAAC, September, 2006. San Francisco, CA.
3. The Stb5 zinc-finger protein is a negative regulator of the yeast-to-hyphae transition in Candida albicans. K.W. Henry, W.L. Smith, J.P. Vermitsky, T.D. Edlind. ASM Conference on Candida and Candidiasis, March 2006. Denver, CO.
4. Pdr1 regulates multidrug resistance in Candida glabrata: Gene disruption and genome-wide expression studies. J.P. Vermitsky, T. Liu, K.W. Henry, P.D. Rogers, T.D. Edlind. ASM Conference on Candida and Candidiasis, March 2006. Denver, CO.
5. Disruption of the Candida albicans STB5 homolog results in constitutive expression of CDR and ERG genes with a paradoxical effect on antifungal susceptibility. K.W. Henry, W.L. Smith, J.P. Vermitsky, T.D. Edlind. ASM Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), December, 2005. Washington, D.C.
6. Candida glabrata PDR1: Genetic, genomic and susceptibility studies. J.P. Vermitsky, W.L. Smith, T. Liu, K.W. Henry, P.D. Rogers, T.D. Edlind. ICAAC, December, 2005. Washington, D.C.
7. Promoter-dependent disruption of genes: simple, rapid and specific PCR-based method with application to three different yeasts. T.D. Edlind, K.W. Henry, J.P. Vermitsky, M.P. Edlind, S. Raj, S.K. Katiyar. Drexel University Discovery Day, October, 2005. Philadelphia, PA.
8. Candida glabrata PDR1: genetic, genomic, and susceptibility studies. J.P. Vermitsky, W.L. Smith, K.W. Henry, T. Liu, P.D. Rogers, T.D. Edlind. 14th Annual Eastern Pennsylvania ASM Infection and Immunity Forum, June, 2005. Philadelphia, PA.
9. Method for screening transcriptional regulators of Saccharomyces cerevisiae multidrug resistance genes. K.W. Henry, J.P. Vermitsky, W.L. Smith, S.L. Berger, T.D. Edlind. ICAAC, November, 2004. Washington, D.C.
10. Novel system for selection of regulatory mutants in Saccharomyces cerevisiae: application to multidrug resistance. M. Edlind, K.W. Henry, T.D. Edlind. Drexel University Discovery Day. October 2004. Philadelphia, PA.
11. Defects in Saccharomyces cerevisiae histone modification alter multidrug transporter gene expression and efflux. E. Bast, T.D. Edlind, K.W. Henry. Drexel University Discovery Day. October 2004. Philadelphia, PA.
12. Transcriptional regulation of multidrug resistance transporters in the opportunistic yeast Candida glabrata. J.P. Vermitsky, A. Khalsa, M. Ayzenerg, K.W. Henry, W.L. Smith, T.D. Edlind. Drexel University Disocvery Day. October 2004. Philadelphia, PA.
13. Chromatin-dependent gene regulation in the yeast antifungal response. K.W. Henry, W.L. Smith, S.L. Berger, and T.D. Edlind. ASM Conference on Candida and Candidiasis, March 2004. Austin, TX.
14. The role of histone ubiquitination in Saccharomyces cerevisiae GAL1 regulation. K.W. Henry, L.J. Duggan, A.M. Wyce, M.A. Osley, and S.L. Berger. The Wistar Institute Symposium, May, 2002. Philadelphia, PA.
15. Rox1p negatively regulates ERG gene expression in Saccharomyces cerevisiae: Implications for susceptibility and resistance to azoles and other sterol biosynthesis inhibitors. K.W. Henry, J.T. Nickels, and T.D. Edlind. ICAAC , September 2000. Toronto, Canada.
16. Calcium-regulated signaling and antifungal tolerance in Candida albicans and Saccharomyces cerevisiae. T.D. Edlind, W.L. Smith, K.W. Henry, S.K. Katiyar, and J.T. Nickels. ICAAC, September 2000. Toronto, Canada.
17. Calcium-regulated signaling mediates tolerance to antifungals. T.D. Edlind, K.W. Henry, W.L. Smith, S.K. Katiyar, and J.T. Nickels. Genetics Society of America Meeting on Yeast Genetics and Molecular Biology, June 2000. Seattle, WA.
18. Upregulation of the Candida albicans ERG11 gene by ergosterol biosynthetic inhibitors and oxygen depletion. K.W. Henry and T.D. Edlind. ICAAC. September, 1999. San Francisco, CA.
19. High frequency azole resistance in Candida: in vitro studies. T.D. Edlind, K.W. Henry, and S.K. Katiyar. ICAAC. September, 1999. San Francisco, CA.
20. Frequency and stability of in vitro azole resistance in Candida species and Cryptococcus neoformans. K.W. Henry, S.K. Katiyar, and T.D. Edlind. ASM Conference on Candida and Candidiasis. March 1999. Charleston, S.C.
21. Induction of multidrug resistance genes in Candida albicans by antimicrobial agents leads to antagonism of azole activity. K.W. Henry and T.D. Edlind. ICAAC. September 1998. San Diego, CA.
22. Genetics of MDR-mediated azole resistance in Saccharomyces cerevisiae. T.D. Edlind, K.W. Henry, S.K. Katiyar. ICAAC. September 1998. San Diego, CA.
23. Reduced azole activity against Candida albicans by antimicrobials correlated with increased expression of multidrug resistance genes. K.W. Henry and T.D. Edlind. Eastern Pennsylvania Branch ASM Infection and Immunity Forum. April 1998. Collegeville, PA.
24. High frequency, unstable azole resistance in Candida albicans. K.W. Henry and T.D. Edlind. Keystone Symposia on Opportunistic Infections in AIDS. April 1998. Keystone, CO.
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